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These drugs are already breaking weight-loss records: in trials involving people with knee osteoarthritis, retatrutide led to an average weight loss of up to 29% after 68 weeks, about 71 pounds, and a reduction in knee pain

In ME/CFS, oxidative stress has emerged as a potential biomarker for fatigue

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Berberine is generally well-tolerated but isn't recommended during pregnancy or breastfeeding